منابع مشابه
STIM1 Juxtaposes ER to Phagosomes, Generating Ca2+ Hotspots that Boost Phagocytosis
BACKGROUND Endoplasmic reticulum (ER) membranes are recruited to phagosomes, but the mechanism and functional significance of this ER recruitment is not known. Here, we show that the ER Ca(2+) sensor stromal interaction molecule 1 (STIM1) sustains high-efficiency phagocytosis by recruiting thin ER cisternae that interact productively but do not fuse with phagosomes. RESULTS Endogenous STIM1 w...
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Dear Editor, In a manuscript by Touret et al. [1], published in the present issue, the authors oppose a so-called " conventional model " of phagocytosis involving the plasma membrane (PM) and early endosomes to an " endoplasmic reticulum (ER)-mediated " model, where the ER is the sole source of initial membrane for the formation of phagosomes. We argue that none of these models integrate accura...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2012
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3468